Key result
Isopropylepinephrine increases cardiac rhythmicity, abolishing carotid sinus-induced cardiac standstill and increasing ventricular rate in complete heart block.
Why the study?
Does isopropylepinephrine increase cardiac rhythmicity in humans with complete heart block or carotid sinus induced cardiac standstill?
Does isopropylepinephrine increase cardiac rhythmicity in humans with complete heart block or carotid sinus induced cardiac standstill?
Isopropylepinephrine increases cardiac rhythmicity and may be of practical value in the therapy and prevention of sudden cardiac standstill.
Answers are grounded in this paper and cite their sources.
May support isopropylepinephrine for standstill prevention in heart block; leaves open confirmation in controlled trials.
Isopropylepinephrine, a non-pressor homologue of epinephrine increases cardiac rhythmicity, as indicated by the abolition of the carotid sinus induced cardiac standstill, and by an increase of the ventricular rate in complete heart block. This drug may be of practical value in the therapy and prevention of sudden cardiac standstill.
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Nathanson et al. (1949) studied this question. Isopropylepinephrine increases cardiac rhythmicity, abolishing carotid sinus-induced cardiac standstill and increasing ventricular rate in complete heart block.
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