Key result
Increasing age (from 20 to 79 years) was associated with a significant linear reduction in the amount of autonomic nerve axons per mm2 of detrusor muscle tissue in urodynamically normal patients.
Population
Urodynamically normal patients aged 20 to 79 years with no subjective evidence of bladder trabeculation at…
Design
Cross-sectional
Authors
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May inform age-related LUTS mechanisms in normal bladders; leaves open causal role and need for longitudinal studies.
Observational
There is a significant age-related reduction in the density of autonomic innervation in the normal human urinary bladder.
Gilpin et al. (1986) conducted an observational in Normal bladder function. Increasing age was evaluated on Amount of autonomic nerve (acetylcholinesterase-positive nerve and nerve per mm2 of detrusor muscle tissue) in bladder biopsy samples. Increasing age (from 20 to 79 years) was associated with a significant linear reduction in the amount of autonomic nerve axons per mm2 of detrusor muscle tissue in urodynamically normal patients.
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