Plasma and Amniotic Fluid Immunoreactive Neuropeptide-Y Level Changes during Pregnancy, Labor, and at Parturition
Key result
Pregnancy was associated with significantly higher mean plasma immunoreactive neuropeptide-Y levels during the first trimester compared to nonpregnant women (129 vs 40 pmol/L, p<0.01).
Why the study?
Do plasma and amniotic fluid immunoreactive neuropeptide-Y (irNPY) levels change during pregnancy, labor, and parturition compared to nonpregnant women?
Population
127 healthy pregnant women and 12 nonpregnant women
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Higher first-trimester irNPY may signal a gestational role; leaves open contributions to labor or clinical relevance.
Study Design
Type
Observational (n=139)
Structured PICO
Do plasma and amniotic fluid immunoreactive neuropeptide-Y (irNPY) levels change during pregnancy, labor, and parturition compared to nonpregnant women?
P
Population
139 healthy women (127 pregnant and 12 nonpregnant) evaluated for plasma and amniotic fluid immunoreactive neuropeptide-Y levels during gestation and parturition.
C
Comparator
Nonpregnant women
O
Outcome
Plasma and amniotic fluid immunoreactive neuropeptide-Y (irNPY) levelssurrogate
Main Result
Absolute Event Rate: 129% vs 40%
p-value: p=<0.01
Plasma and amniotic fluid irNPY levels are elevated during pregnancy and further increase during the stress of labor, suggesting a possible role for NPY in human pregnancy and parturition.
Cite This Study
Petraglia et al. (1989) conducted an observational in Pregnancy (n=139). Pregnancy vs. Nonpregnant state was evaluated on Mean plasma immunoreactive neuropeptide-Y (irNPY) concentration (p=<0.01). Pregnancy was associated with significantly higher mean plasma immunoreactive neuropeptide-Y levels during the first trimester compared to nonpregnant women (129 vs 40 pmol/L, p<0.01).