Key result
In older men with treatment-resistant depression, a bimodal age of onset was observed (75% before age 35, 25% after age 50), with high lifetime rates of anxiety (88%) and alcoholism (70%).
Observational
Older men with chronic, treatment-resistant depression often have a complex lifetime psychiatric history characterized by early-onset anxiety and high rates of comorbid alcoholism.
Authors
No takes yet. Share an insight, caveat, or question.
Supports thorough psychiatric comorbidity assessment in older men with treatment-resistant depression; leaves open causal links and targeted interventions.
Rohrbaugh et al. (1989) conducted an observational in Chronic depression. Chronic depression was evaluated on Age of onset of first major depression and lifetime comorbidities. In older men with treatment-resistant depression, a bimodal age of onset was observed (75% before age 35, 25% after age 50), with high lifetime rates of anxiety (88%) and alcoholism (70%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: