Key result
Serum ferritin levels were negatively correlated with cardiac T2 MRI findings, while heart rate recovery at 1 minute showed a positive correlation with cardiac T2.
Cross-Sectional (n=57)
Single-blind
No
Serum ferritin levels and heart rate recovery correlate significantly with cardiac T2 MRI findings, suggesting they can be used to predict myocardial iron load and autonomic dysfunction in beta thalassemia major patients.
Answers are grounded in this paper and cite their sources.
HRR correlates with T2 in TM; leaves open whether it refines screening or risk stratification beyond ferritin and MRI.
BACKGROUND: It is generally well-understood that iron-mediated cardiomyopathy is the major complication that can arise from beta thalassemia major (TM). Therefore, early diagnosis, risk stratification, and the effective treatment of beta TM patients are clinically important to optimize long-term positive outcomes. METHODS: This study included 57 beta TM patients with a mean age of 25 ± 7 years. We determined the serum ferritin level, echocardiography, heart rate recovery (HRR), and cardiac magnetic resonance (CMR) T2* in all patients. CMR T2* findings were categorized as normal myocardium (T2* > 20 ms), and myocardial involvement (T2* ≤ 20 ms). HRR values at 1-5 min (HRR1-5) were recorded; Subsequently. HRR was calculated by subtracting the heart rate at each time point from the heart rate at peak exercise. RESULTS: There was a significant negative correlation between the serum ferritin level and the cardiac T2* MRI findings (r = -0.34, p = 0.009). A similar result was found in the negative correlation between serum ferritin and all heart rate recovery values. There was a significant positive correlation between HRR1, HRR2, and HRR3 values, and CMR T2* (T2* heart rate recovery (HRR)1: r = 0.51, p < 0.001; T2* HRR2: r = 0.48, p < 0.001; T2* HRR3: r = 0.47, p < 0.001, respectively). CONCLUSIONS: The serum ferritin level and echocardiography can be used to predict the presence of myocardial iron load in beta TM patients. Therefore, HRR can be used to screen beta TM patients, and the clinical use of HRR can be a predictive marker for autonomic dysfunction in beta TM patients.
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Yüksel et al. (2016) conducted a cross-sectional in Beta Thalassemia Major (n=57). Serum ferritin level and Heart Rate Recovery was evaluated on Correlation between serum ferritin level and cardiac T2 MRI findings (r = -0.34, p=0.009). Serum ferritin levels were negatively correlated with cardiac T2 MRI findings, while heart rate recovery at 1 minute showed a positive correlation with cardiac T2.
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