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January 1, 2022Journal of Research in Medical SciencesOpen Access

T2-weighted cardiovascular magnetic resonance and echocardiographic arterial elasticity criteria for monitoring cardiac siderosis in patients with beta-thalassemia major

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Key result

CMR T2* positively correlates with arterial elastance index in asymptomatic beta-thalassemia major.

  • r = 0.258
  • P=0.035
  • n=67

Why the study?

Despite iron chelators, iron toxicity remains the leading cause of death in thalassemia major patients, prompting evaluation of CMR T2* and echocardiographic arterial elasticity for monitoring.

Does echocardiographic arterial elasticity correlate with CMR T2* in patients with major beta-thalassemia without cardiac symptoms?

Population

67 major beta-thalassemia patients without cardiac symptoms in Isfahan, Iran

Design

Cross-sectional study

Authors

RZReihaneh ZavarMHMoien HendimarjanMBMohaddeseh Behjati

Discussion

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Overview

Echo arterial elasticity may correlate with CMR T2* in asymptomatic thalassemia; leaves open prospective validation before clinical use.

Study Design

Type

Cross-Sectional (n=67)

Multicenter

No

Structured PICO

Does echocardiographic arterial elasticity correlate with CMR T2* in patients with major beta-thalassemia without cardiac symptoms?

P
Population
67 patients with major beta-thalassemia without cardiac symptoms assessed for the association between CMR T2*, echocardiographic arterial elasticity, and serum ferritin.
E
Exposure
Cardiovascular magnetic resonance using T2-weighted sequences (CMR T2*) and echocardiographic arterial elasticity assessment
O
Outcome
Correlation between CMR T2*, echocardiographic arterial elasticity criteria, and serum ferritinsurrogate

Main Result

Effect estimate: r = 0.258

p-value: p=0.035

Arterial elastance index from echocardiography correlates with CMR T2* and may serve as an indicator of myocardial iron overload in asymptomatic patients with beta-thalassemia major.

Cite This Study

Zavar et al. (2022) conducted a cross-sectional in major beta-thalassemia (n=67). CMR T2* was evaluated on Correlation between CMR T2* and arterial elastance index (r = 0.258, p=0.035). CMR T2* showed a positive correlation with the arterial elastance index (r = 0.258, P = 0.035) in patients with major beta-thalassemia without cardiac symptoms.

synapsesocial.com/papers/6aaa581ac85bdfeaa654cae4https://doi.org/10.4103/jrms.jrms_705_21
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation of myocardial T2* to right ventricular function in thalassaemia major2010 · 47 citations
  2. 2Correlation between Heart, Liver and Pancreas Hemosiderosis Measured by MRI T2* among Thalassemia Major Patients from Iran.2016 · 26 citations