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December 8, 2025Blood

An echocardiography and ferritin-based screening model to optimise cardiac T2* MRI use for detecting myocardial iron overload in transfusion-dependent thalassemia patients

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Authors

RSRudra Narayan SwainAGAnkur GuptaAJAditya Jandial

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Overview

Echocardiography and ferritin levels identify cardiac iron overload in transfusion-dependent thalassemia, suggesting improved screening methods.

Key Points

  • To evaluate a screening model combining echocardiography and ferritin to detect myocardial iron overload in thalassemia patients.
  • Enrolled 64 transfusion-dependent thalassemia patients aged 15.8 years.
  • Performed two-dimensional echocardiography and T2* CMR within six months.
  • Used multivariate logistic regression analyzing echocardiographic and ferritin data.
  • Cardiac siderosis was present in 19% (12 out of 64) of patients.
  • Model using five parameters achieved 92% sensitivity and 80% specificity for iron overload.
  • A simple screening using septal S' < 8 cm/s or ferritin > 1,850 ng/mL identified 92% of patients with cardiac siderosis.

Cite This Study

Swain et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcaehttps://doi.org/10.1182/blood-2025-943
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1T2-weighted cardiovascular magnetic resonance and echocardiographic arterial elasticity criteria for monitoring cardiac siderosis in patients with beta-thalassemia major2022 · 4 citations
  2. 2Quantification of myocardial iron deposition by two-dimensional speckle tracking in patients with β-thalassaemia major and Blackfan–Diamond anaemia2011 · 38 citations
  3. 3The correlation between cardiac magnetic resonance T2* and left ventricular global longitudinal strain in people with β‐thalassemia2018 · 23 citations
  4. 4The Association between Serum Ferritin Level, Tissue Doppler Echocardiography, Cardiac T2* MRI, and Heart Rate Recovery in Patients with Beta Thalassemia Major.2016 · 23 citations
  5. 5Increased sympathovagal imbalance evaluated by heart rate variability is associated with decreased T2* MRI and left ventricular function in transfusion-dependent thalassemia patients2018 · 5 citations