Key result
Cholesterol facilitated the removal of emulsion particles from plasma, whereas sphingomyelin delayed particle removal and reduced lipolysis rates in rat models.
Population
Rats and in vitro models
Comparison
Lipid emulsions containing sphingomyelin or… vs Lipid emulsions with differing surface…
Design
Preclinical
Authors
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Should not yet change clinical lipid emulsion use; leaves open surface lipid effects on human lipoprotein kinetics.
Sphingomyelin and cholesterol in the lipoprotein surface play a critical role in regulating the circulation behavior and LPL-mediated lipolysis of lipid emulsions by altering plasma protein binding selectivity.
Arimoto et al. (1998) studied this question. Sphingomyelin and cholesterol in lipid emulsions was evaluated on Plasma clearance and lipolysis rates. Cholesterol facilitated the removal of emulsion particles from plasma, whereas sphingomyelin delayed particle removal and reduced lipolysis rates in rat models.
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