Key result
Single renal vein occlusion in anesthetized dogs reflexly decreased right ventricular contractile force by 6% to 25% and inhibited contralateral renal and cardiopulmonary sympathetic nerve activity.
Population
Dogs anesthetized with pentobarbital sodium
Comparison
Occlusion of a single renal vein vs Denervation of the congested kidney
Design
Preclinical
Authors
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Renal venous pressure may reflexly modulate RV contractility via sympathetic pathways; leaves open relevance to human cardiorenal syndromes.
Renal afferents activated by increased renal venous pressure can reflexly inhibit cardiopulmonary sympathetic efferent nerve activity and decrease right ventricular contractile force.
Kostreva et al. (1981) studied this question. Single renal vein occlusion vs. Denervation of the congested kidney was evaluated on Right ventricular contractile force. Single renal vein occlusion in anesthetized dogs reflexly decreased right ventricular contractile force by 6% to 25% and inhibited contralateral renal and cardiopulmonary sympathetic nerve activity.
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