January 1, 1967Japanese Heart JournalOpen Access

Mechanism of the Reflex Depressor Effect by Kidney in Dog

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Population

36 mongrel dogs anesthetized with penthobarbitone sodium under artificial breathing

Comparison

Alteration of intrarenal pressure via kidney… vs Baseline state prior to manipulation

Design

Preclinical

Authors

HUHideo UEDAJosai University YUYasumi UchidaTsukuba Memorial Hospital KKKazuaki KAMISAKANational Institute of Arthritis and Musculoskeletal and Skin Diseases

Discussion

Member takes

Implication

Preclinical renal baroreflex evidence in animals; leaves open translation to human hypertension therapies.

Structured PICO

Population

36 mongrel dogs anesthetized with penthobarbitone sodium under artificial breathing

Intervention

Alteration of intrarenal pressure via kidney compression, renal vein occlusion, renal artery occlusion, and electric stimulation of the afferent renal nerve

Comparator

Baseline state prior to manipulation

Outcome

Changes in action potentials of the efferent and afferent renal nerves and systemic arterial pressuresurrogate

This preclinical study demonstrates that receptors sensitive to intrarenal pressure changes can activate a reflex hypotension by inhibiting sympathetic discharge.

Limitations

Capsules of the hili where vessels and nerves enter may not have been resected completely, leaving the possibility that afferent fibers arise from the capsule.

Cite This Study

UEDA et al. (1967) studied this question.

synapsesocial.com/papers/6a8ae3c2f71fc1553cbe94a4 https://doi.org/10.1536/ihj.8.597

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Mechanism of the Reflex Depressor Effect by Kidney in Dog

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Mechanism of the Reflex Depressor Effect by Kidney in Dog

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider