January 1, 1981AJP Renal Physiology
Renal function during reflexly activated catecholamine flow through an adrenorenal rete
Key result
Reflex activation of catecholamine flow through an adrenorenal rete produced a 26% decrease in renal plasma flow, 23% decrease in GFR, and 58% decrease in urinary sodium excretion in dogs.
Population
Sodium-replete pentobarbital-anesthetized dogs
Comparison
Reflex activation of catecholamine flow through… vs Reflex activation of renal sympathetic nerves in…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for adrenorenal catecholamine reflexes in renal volume control; leaves open translation to human physiology.
Structured PICO
P
Population
Sodium-replete pentobarbital-anesthetized dogs undergoing experimentally induced atrial fibrillation to cause transient hypotension.
I
Intervention
Reflex activation of catecholamine flow through an adrenorenal rete (via transient hypotension from experimentally induced atrial fibrillation), with and without intrarenal angiotensin II blockade using [Sar1,Ala8]angiotensin II
C
Comparator
Reflex activation of renal sympathetic nerves in kidneys with intact or ligated adrenorenal rete
O
Outcome
Changes in renal function (renal plasma flow, glomerular filtration rate, urinary sodium excretion, filtration fraction, fractional distribution of intrarenal blood flow)surrogate
Both reflex activation of catecholamine flow through an adrenorenal rete and renal sympathetic nerves are important, angiotensin II-independent mechanisms for maintaining vascular volume in the kidney.
Cite This Study
Katholi et al. (1981) studied Transient hypotension. Reflex activation of catecholamine flow through an adrenorenal rete vs. Reflex activation of renal sympathetic nerves was evaluated on Changes in renal function (renal plasma flow, glomerular filtration rate, urinary sodium excretion). Reflex activation of catecholamine flow through an adrenorenal rete produced a 26% decrease in renal plasma flow, 23% decrease in GFR, and 58% decrease in urinary sodium excretion in dogs.