Key result
Intrarenal adenosine infusion produced a 21 ± 3 mmHg rise in mean arterial pressure and increased plasma norepinephrine in dogs with intact renal nerves, but not after renal denervation.
Why the study?
Does intrarenal adenosine infusion increase arterial pressure and sympathetic nervous system activity in dogs?
Population
Uninephrectomized sodium replete conscious dogs and α-chloralose-anaesthetized dogs
Comparison
Intrarenal adenosine infusion vs Before and after renal denervation, and control…
Design
Preclinical
Authors
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No clinical implications yet; leaves open translation of renal adenosine sympathoexcitation from canine models.
Does intrarenal adenosine infusion increase arterial pressure and sympathetic nervous system activity in dogs?
Mean Difference: 21
Intrarenal adenosine produces hypertension by activating the sympathetic nervous system via intact renal nerves in a canine model.
Katholi et al. (1984) studied Hypertension. Intrarenal adenosine infusion vs. Before infusion and after renal denervation was evaluated on Mean arterial pressure (21 ± 3 mmHg rise). Intrarenal adenosine infusion produced a 21 ± 3 mmHg rise in mean arterial pressure and increased plasma norepinephrine in dogs with intact renal nerves, but not after renal denervation.
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