Key result
The dynamic properties of aortic baroreceptors in rabbits may not be related to wall mechanics or Na(+)-K(+)-ATPase activity, as the pressure-diameter relationship showed no hysteresis.
The dynamic properties of aortic baroreceptors appear to be unrelated to wall mechanics or Na(+)-K(+)-ATPase activity.
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Animal findings in rabbits warrant no clinical translation; leaves open baroreceptor mechanisms for prospective human studies.
To examine the contribution of wall mechanics to dynamic properties of baroreceptors, we subdivided the transfer function of baroreceptors into two subsystems [aortic pressure to diameter and diameter to aortic depressor nerve activity (ANA)]. In six alpha-chloralose-anesthetized rabbits, we measured pressure, diameter, and ANA while randomly perturbing pressure. We obtained transfer functions (pressure to ANA, diameter to ANA, and pressure to diameter) by taking the ratio of crosspower spectrum to the input power spectrum (0.005-5 Hz). Below 3 Hz, the transfer function from pressure to ANA was nearly identical to that from diameter to ANA, whereas that from pressure to diameter was flat. Using transfer functions we could reproduce adaptation and hysteresis that were quantitatively similar between pressure-ANA transduction and diameter-ANA transduction. The pressure-diameter relationship was almost instantaneous and thus showed no hysteresis. In a second group of rabbits, the ratio of the shift of the hysteresis loop was unchanged by ouabain (40 micrograms/kg iv, n = 7). We conclude that the dynamic properties of baroreceptors may not be related to the wall mechanics or the Na(+)-K(+)-adenosinetriphosphatase activity.
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Imaizumi et al. (1993) studied Aortic baroreceptor dynamic properties (n=13). Ouabain was evaluated on Transfer functions of baroreceptors and hysteresis loop shift. The dynamic properties of aortic baroreceptors in rabbits may not be related to wall mechanics or Na(+)-K(+)-ATPase activity, as the pressure-diameter relationship showed no hysteresis.
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