Key result
Prosthetic valve endocarditis was associated with a higher risk of overall mortality compared to native valve endocarditis following surgery for infective endocarditis.
Why the study?
With a growing number of patients undergoing prosthetic heart valve replacement, PVE incidence has increased, warranting an analysis of patterns and outcomes of PVE surgery compared with NVE.
Does surgery for prosthetic valve endocarditis increase overall mortality compared to native valve endocarditis in patients with infective endocarditis?
Cohort (n=269)
No
Does surgery for prosthetic valve endocarditis increase overall mortality compared to native valve endocarditis in patients with infective endocarditis?
Prosthetic valve endocarditis carries significant perioperative risks and is an independent risk factor for overall mortality following valve surgery compared to native valve endocarditis.
Answers are grounded in this paper and cite their sources.
Prosthetic valve endocarditis warrants heightened post-surgical vigilance; leaves open whether targeted strategies can reduce excess mortality.
BACKGROUND AND OBJECTIVES: As a consequence of a growing number of patients undergoing prosthetic heart valve replacement, the incidence of prosthetic valve endocarditis (PVE) has increased. The study aims to analyze patterns and outcomes of PVE surgery as compared with native valve endocarditis (NVE). METHODS: We enrolled 269 patients (aged 58.0±15.7 years) who underwent valve surgery for infective endocarditis (IE) between 2013 and 2019. Of these, 56 had PVE whereas remainder (n=213) had NVE. Clinical outcomes were compared and multivariable analyses were conducted to determine risk factors for mortality. RESULTS: or fungus were independent risk factors of overall mortality. CONCLUSIONS: PVE carried significant perioperative risks, and was an independent risk factor of overall mortality.
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Pyo et al. (2021) conducted a cohort in Infective endocarditis requiring valve surgery (n=269). Prosthetic valve endocarditis vs. Native valve endocarditis was evaluated on Overall mortality (HR 2.67, 95% CI 1.40-5.07, p=0.003). Prosthetic valve endocarditis was associated with a higher risk of overall mortality compared to native valve endocarditis following surgery for infective endocarditis.
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