Key result
Radioactive poliovirus binding activity was found mainly in membranous fractions of low electrophoretic mobility in HeLa and human esophageal cells, whereas rat heart and L cells showed no binding.
Population
Cultured cells and their postnuclear fractions
Design
Preclinical
Authors
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Cell-specific poliovirus binding in vitro warrants caution extrapolating to tissues; leaves open receptor roles in human infection.
Poliovirus binding activity varies among different cultured cell lines and is localized to specific membranous fractions.
H.V. Thorne (1963) studied Poliovirus binding to cultured cell components. P(32)-labeled poliovirus was evaluated on Virus-binding activity of cell homogenate components. Radioactive poliovirus binding activity was found mainly in membranous fractions of low electrophoretic mobility in HeLa and human esophageal cells, whereas rat heart and L cells showed no binding.
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