Key result
Mechanical valves showed no difference in prosthetic valve endocarditis risk compared to bioprosthetic valves, whereas active endocarditis at operation was a strong predictor (7.4% vs 0.9%, p=0.001).
Why the study?
Does the type of prosthetic valve (mechanical vs bioprosthetic) affect the risk of developing prosthetic valve endocarditis?
RCT (n=1,032)
randomized
Yes
Does the type of prosthetic valve (mechanical vs bioprosthetic) affect the risk of developing prosthetic valve endocarditis?
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Active endocarditis at the time of operation is the strongest predictor of prosthetic valve endocarditis, while the choice between mechanical and bioprosthetic valves does not significantly affect this risk.
Grover et al. (1994) conducted an RCT in Valvular Heart Disease (n=1,032). Mechanical valve (Bjork-Shiley spherical disc) vs. Bioprosthetic valve (Hancock porcine heterograft) was evaluated on Prosthetic valve endocarditis. Mechanical valves showed no difference in prosthetic valve endocarditis risk compared to bioprosthetic valves, whereas active endocarditis at operation was a strong predictor (7.4% vs 0.9%, p=0.001).
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