Key result
Diabetic patients with retinopathy had significantly increased plasma beta-thromboglobulin levels and shorter platelet survival times compared to those without vascular complications, indicating increased platelet utilization.
Observational (n=43)
Yes
Diabetic patients with retinopathy exhibit increased platelet utilization, as evidenced by shorter platelet survival time and elevated plasma β-thromboglobulin.
Supports platelet activation in diabetic retinopathy; hypothesis-generating and requires prospective validation before any clinical implications.
Occlusive vascular disease is a major complication of diabetes mellitus. This may reflect intrinsic disease in the vessel walls, an increased tendency to intravascular thrombosis, diminished lysis or to a combination of these factors. The measurement of platelet survival time offers a potentially useful assessment of the dynamic state of the haemostatic mechanism. This study was carried out to observe platelet survival time, plasma β-thromboglobulin (β-TG), platelet aggregation, platelet adhesiveness and the percentage of megathrombocyte to peripheral blood platelet counts in diabetic subjects without vascular complication (group A) and with diabetic retinopathy (group B).The results obtained in this paper were as follows:1) Plasma β-TG was significantly increased in 19 group B patients compared to controls, but not increased in 24 group A patients.2) In two patients with diabetic retinopathy, platelet survival time was shorter, and the percentage of megathrombocyte and β-TG were increased.3) Plasma β-TG was not significantly correlated with platelet aggregation induced by ADP, collagen or adrenaline and platelet adhesiveness.4) Platelet survival time was significantly correlated with plasma β-TG levels and the percentage of megathrombocyte in diabetic subjects.In summary, it is concluded that there is an increased utilization of platelets in diabetic subjects with retinopathy.
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Arai et al. (1980) conducted an observational in Diabetes mellitus (n=43). Diabetic retinopathy vs. Diabetes without vascular complications and healthy controls was evaluated on Plasma beta-thromboglobulin (B-TG) and platelet survival time. Diabetic patients with retinopathy had significantly increased plasma beta-thromboglobulin levels and shorter platelet survival times compared to those without vascular complications, indicating increased platelet utilization.
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