Key result
Angiotensin II perfusion resulted in a dose-dependent decrease in blood flow, lipolysis, and glucose uptake in subcutaneous adipose tissue of young healthy men.
Why the study?
Does Angiotensin II affect blood flow and metabolism in subcutaneous adipose tissue in young healthy men?
Population
14 young healthy men (n=8 in protocol 1, n=6 in protocol 2)
Comparison
Microdialysis perfusion with Angiotensin II and… vs Perfusion with Ringer's solution + 50 mM ethanol…
Authors
Loading...
No immediate clinical implications; hypothesis-generating for Ang II effects on adipose metabolism in cardiometabolic disease.
Does Angiotensin II affect blood flow and metabolism in subcutaneous adipose tissue in young healthy men?
Angiotensin II inhibits lipolysis and decreases blood flow in subcutaneous adipose tissue, with regional differences in sensitivity.
Boschmann et al. (2001) studied Healthy (n=14). Angiotensin II vs. Baseline / Isoproterenol alone was evaluated on Blood flow, lipolysis, and glycolysis. Angiotensin II perfusion resulted in a dose-dependent decrease in blood flow, lipolysis, and glucose uptake in subcutaneous adipose tissue of young healthy men.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: