Key result
Experimental myocardial infarction in rabbits led to structural remodeling of cardiomyocytes in the border zone, including a significant increase in vacuole area/total cell area ratio from 3.7% at 2 weeks to 7.1% at 12 weeks.
Population
Rabbit hearts subjected to left coronary artery (LAD) ligation
Comparison
LAD ligation (myocardial infarction model) vs Non-infarcted control heart
Design
Preclinical
Follow-up
2, 4, 8 and 12 weeks post-infarction
Authors
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Does not support clinical translation; leaves open translational relevance of border-zone vacuolization in post-MI remodeling.
Absolute Event Rate: 7.1% vs 3.7%
p-value: p=<0.05
Cardiomyocyte remodeling mechanisms, including vacuolization and hypertrophy, occur in the border zone and adjacent regions of infarcted rabbit myocardium from 2 to 12 weeks post-infarction.
Driesen et al. (2007) studied Myocardial infarction (n=5). LAD ligation vs. Non-infarcted control heart / remote zone was evaluated on Vacuole area/total cell area ratio at 12 weeks vs 2 weeks post-infarction (p=<0.05). Experimental myocardial infarction in rabbits led to structural remodeling of cardiomyocytes in the border zone, including a significant increase in vacuole area/total cell area ratio from 3.7% at 2 weeks to 7.1% at 12 weeks.
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