Key result
The oxidation of the NOS ferrous heme-NO complex by O2 proceeds by a rapid direct reaction rather than heme-NO dissociation.
This study reveals a novel mechanism for the oxidation of the NOS ferrous heme-NO complex by O2, distinguishing heme-thiolate enzymes from related heme proteins.
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No immediate clinical impact; leaves open relevance of this NOS mechanism to human cardiovascular physiology.
Tejero et al. (2009) studied this question. Reaction of O2 with ferrous heme-NO complexes was evaluated on Mechanism of oxidation of the NOS ferrous heme-NO complex by O2. The oxidation of the NOS ferrous heme-NO complex by O2 proceeds by a rapid direct reaction rather than heme-NO dissociation.
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