Key result
Mink parvoviruses (Aleutian disease virus and mink enteritis virus) neither induced nor were sensitive to interferon, and preexisting infections did not inhibit interferon production in vitro.
Autonomously replicating mink parvoviruses replicate independently of the interferon system in vitro.
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Does not support interferon-based interventions for mink parvovirus infections; leaves open in vivo relevance of interferon-independent replication.
Although interferons can inhibit the replication of a number of viruses, little is known about their ability to inhibit parvovirus replication. Therefore, in vitro experiments were done to determine if Aleutian disease virus and mink enteritis virus, two autonomously replicating mink parvoviruses, induced interferon, were sensitive to the effects of interferon, or inhibited the production of interferon. The results indicated that these parvoviruses neither induced nor were sensitive to the effects of interferon. Furthermore, preexisting parvovirus infections did not inhibit poly(I).poly(C)-induced interferon production. This independence from the interferon system may, therefore, be a general property of the autonomously replicating parvoviruses.
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WIEDBRAUK et al. (1986) studied Parvovirus infection (in vitro). Interferon or Parvovirus infection vs. Control cell monolayers was evaluated on Interferon production and virus yield. Mink parvoviruses (Aleutian disease virus and mink enteritis virus) neither induced nor were sensitive to interferon, and preexisting infections did not inhibit interferon production in vitro.
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