Key result
The use of 5'-levulinyl and 2'-tetrahydrofuranyl protecting groups enabled the successful synthesis of oligoribonucleotides, including four decamers and a heneicosamer, in good yields.
Population
Oligoribonucleotide synthesis model
Design
Preclinical
Authors
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May aid RNA tool development for cardiovascular research; leaves open therapeutic translation.
The levulinyl group can be effectively used for 5'-hydroxyl protection in oligoribonucleotide synthesis.
Iwai et al. (1988) studied this question. 5'-Levulinyl and 2'-tetrahydrofuranyl protection was evaluated on Synthesis of oligoribonucleotides. The use of 5'-levulinyl and 2'-tetrahydrofuranyl protecting groups enabled the successful synthesis of oligoribonucleotides, including four decamers and a heneicosamer, in good yields.
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