Key result
LOT-aCRT significantly reduced QRS duration to 121.0 ms compared to 133.3 ms with conventional biventricular pacing in patients with systolic heart failure and left bundle branch block.
Why the study?
Left bundle branch area pacing has shown encouraging results as an alternative option for adaptive cardiac resynchronization therapy, but the feasibility and outcomes of combining it with coronary venous pacing remained to be assessed.
Does LOT-aCRT improve QRS duration and left ventricular function compared to conventional BVP-aCRT in patients with systolic heart failure and LBBB?
Observational (n=21)
No
Does LOT-aCRT improve QRS duration and left ventricular function compared to conventional BVP-aCRT in patients with systolic heart failure and LBBB?
Absolute Event Rate: 121% vs 133.3%
p-value: p=<0.01
LOT-aCRT is a clinically feasible alternative to conventional biventricular pacing that may offer superior electrical resynchronization and LV function improvement in patients with systolic heart failure and LBBB.
No takes yet. Share an insight, caveat, or question.
May support LOT-aCRT feasibility in HF with LBBB; leaves open outcome confirmation versus standard aCRT in RCTs.
Feng et al. (2022) conducted an observational in Systolic heart failure with left bundle branch block (n=21). Adaptive left bundle branch-optimized cardiac resynchronization therapy (LOT-aCRT) vs. Conventional biventricular pacing (BVP-aCRT) was evaluated on QRS duration at 9 months (p=<0.01). LOT-aCRT significantly reduced QRS duration to 121.0 ms compared to 133.3 ms with conventional biventricular pacing in patients with systolic heart failure and left bundle branch block.
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