Key result
Granulocyte colony-stimulating factor (G-CSF) ameliorated the development of cardiac fibrosis and hypertrophy in mice with Angiotensin II-induced cardiac remodelling.
Why the study?
Does G-CSF reduce cardiac remodelling in mice with angiotensin II-induced hypertrophy?
Population
Mice model of angiotensin II-induced cardiac hypertrophy
Comparison
Recombinant human G-CSF on the first 5 days of… vs Angiotensin II infusion alone or saline control
Design
Preclinical
Follow-up
4 weeks
Authors
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Should not change practice; hypothesis-generating in Ang II mouse models and leaves human translation open.
Does G-CSF reduce cardiac remodelling in mice with angiotensin II-induced hypertrophy?
G-CSF attenuates angiotensin II-induced cardiac remodeling in mice, suggesting a potential therapeutic mechanism involving ACE isoform modulation.
Jia et al. (2008) studied Angiotensin II-induced cardiac hypertrophy. Granulocyte colony-stimulating factor (G-CSF) vs. Control group / AngII alone was evaluated on Cardiac hypertrophy and fibrosis. Granulocyte colony-stimulating factor (G-CSF) ameliorated the development of cardiac fibrosis and hypertrophy in mice with Angiotensin II-induced cardiac remodelling.
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