Key result
Children with a history of Kawasaki disease and coronary aneurysms had a significantly higher carotid artery stiffness index (5.07 vs 4.24, p=0.001) and hs-CRP levels compared to healthy controls.
Why the study?
Does a history of Kawasaki disease with coronary aneurysms increase hs-CRP concentrations and arterial stiffness in children?
Population
106 children, comprising 43 patients with a history of Kawasaki disease with coronary aneurysms, 28 patients…
Comparison
History of Kawasaki disease with coronary… vs Healthy age-matched children
Design
Cohort
Authors
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May signal persistent vascular risk in Kawasaki survivors with aneurysms; hypothesis-generating for inflammation-stiffness link, needs prospective trials.
Cohort (n=106)
Does a history of Kawasaki disease with coronary aneurysms increase hs-CRP concentrations and arterial stiffness in children?
Absolute Event Rate: 5.07% vs 4.24%
p-value: p=0.001
Children with a history of Kawasaki disease and coronary aneurysms exhibit persistent low-grade inflammation and increased arterial stiffness compared to those without aneurysms and healthy controls.
Yiu‐fai Cheung (2004) conducted a cohort in Kawasaki disease (n=106). History of Kawasaki disease with coronary aneurysms vs. Healthy age-matched children was evaluated on Carotid artery stiffness index (p=0.001). Children with a history of Kawasaki disease and coronary aneurysms had a significantly higher carotid artery stiffness index (5.07 vs 4.24, p=0.001) and hs-CRP levels compared to healthy controls.
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