Key result
Adolescents with Kawasaki disease and coronary artery lesions had significantly higher carotid intima-media thickness (0.53 vs 0.46 mm, P<0.05) and arterial stiffness compared to healthy controls.
Why the study?
Does Kawasaki disease with coronary artery lesions increase carotid intima-media thickness and arterial stiffness in adolescents compared to healthy controls?
Population
40 adolescents, comprising 20 with Kawasaki disease and coronary artery lesions and 20 sex- and age-matched…
Comparison
Kawasaki disease with coronary artery lesions vs Sex- and age-matched healthy controls
Design
Case-control
Authors
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May support carotid IMT monitoring for early atherosclerosis risk in KD children with CAL; leaves open whether findings predict clinical events.
Case-Control (n=40)
Does Kawasaki disease with coronary artery lesions increase carotid intima-media thickness and arterial stiffness in adolescents compared to healthy controls?
Absolute Event Rate: 0.53% vs 0.46%
p-value: p=<.05
Adolescents with Kawasaki disease and coronary artery lesions exhibit increased carotid intima-media thickness and arterial stiffness compared to healthy controls, suggesting a predisposition to accelerated atherosclerosis.
Noto et al. (2001) conducted a case-control in Kawasaki disease and coronary artery lesions (n=40). Kawasaki disease and coronary artery lesions vs. Healthy controls was evaluated on Carotid intima-media thickness (IMT) (p=<.05). Adolescents with Kawasaki disease and coronary artery lesions had significantly higher carotid intima-media thickness (0.53 vs 0.46 mm, P<0.05) and arterial stiffness compared to healthy controls.
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