Key result
Children with acute Kawasaki disease had a significantly higher common carotid artery intima-media thickness compared to febrile controls (0.550 mm vs. 0.483 mm, P=0.01).
Why the study?
Does common carotid artery intima-media thickness measurement help diagnose the acute stage of Kawasaki disease in febrile children?
Case-Control (n=35)
Single-blind
No
Does common carotid artery intima-media thickness measurement help diagnose the acute stage of Kawasaki disease in febrile children?
Common carotid artery intima-media thickness is significantly increased during the acute stage of Kawasaki disease compared to other febrile illnesses, suggesting its potential utility as an early noninvasive diagnostic adjunct.
Answers are grounded in this paper and cite their sources.
cIMT may aid acute Kawasaki diagnosis in febrile children; leaves open prospective validation before clinical use.
BACKGROUND: This study aimed to investigate intima-media thickness (IMT) of the common carotid arteries in children with acute Kawasaki disease (KD). METHODS: Between 2009 and 2011, patients fulfilling the criteria for KD, including a fever lasting >5 days, were prospectively enrolled in this study. Laboratory data, echocardiography, and IMT were measured and compared with matched controls. RESULTS: A total of 70 common carotid IMTs were measured in 35 children. We studied 21 patients aged 3-60 months old with acute KD and 14 febrile patients aged 3-194 months old with acute infection and similar characteristics to those of KD patients. Children with KD had a significantly higher IMT compared with the controls (0.550 ± 0.081 mm vs. 0.483 ± 0.046 mm, P = 0.01). CONCLUSIONS: IMT during the acute stage of KD is increased, suggesting that IMT could be a useful diagnostic tool in the early diagnosis of KD.
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Wu et al. (2014) conducted a case-control in Acute Kawasaki disease (n=35). Acute Kawasaki disease vs. Febrile controls with acute infections was evaluated on Common carotid artery intima-media thickness (IMT) (p=0.01). Children with acute Kawasaki disease had a significantly higher common carotid artery intima-media thickness compared to febrile controls (0.550 mm vs. 0.483 mm, P=0.01).
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