Why the study?
Does a history of Kawasaki disease increase arterial stiffness (measured by PWV, ABI, and cIMT) in children who have recovered?
Population
80 children, including 25 patients who recovered from Kawasaki disease with coronary aneurysm and 55 healthy…
Comparison
History of Kawasaki disease with coronary… vs Healthy children with no history of Kawasaki…
Design
Case-control, Single-blind.
Follow-up
>8 years since recovery from Kawasaki disease
Key result
A history of Kawasaki disease with coronary aneurysms was associated with significantly higher left brachial-ankle pulse wave velocity compared to healthy controls (1020.6 vs 984.0 cm/sec, p<0.05), indicating increased arterial stiffness.
Authors
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Supports vascular monitoring in Kawasaki survivors with aneurysms; hypothesis-generating for prospective pediatric outcome studies.
Case-Control (n=80)
Single-blind
No
Does a history of Kawasaki disease increase arterial stiffness (measured by PWV, ABI, and cIMT) in children who have recovered?
Absolute Event Rate: 1020.6% vs 984%
p-value: p=<0.05
Children who recovered from Kawasaki disease with coronary aneurysms exhibit increased arterial stiffness (higher pulse wave velocity) compared to healthy controls, suggesting a need for long-term cardiovascular follow-up.
Lee et al. (2009) conducted a case-control in Kawasaki disease (n=80). History of Kawasaki disease with coronary aneurysm vs. Healthy children was evaluated on Left brachial-ankle pulse wave velocity (LbaPWV) (p=<0.05). A history of Kawasaki disease with coronary aneurysms was associated with significantly higher left brachial-ankle pulse wave velocity compared to healthy controls (1020.6 vs 984.0 cm/sec, p<0.05), indicating increased arterial stiffness.