Why the study?
Does a history of Kawasaki disease increase carotid intima-media thickness (a surrogate marker of cardiovascular risk) in children and young adults compared to unaffected controls?
Population
161 children and young adults with a history of Kawasaki disease and 82 unaffected controls. KD patients had…
Comparison
History of Kawasaki disease vs Unaffected controls without a history of KD and…
Design
Cross-sectional, 1 image analyst blinded for case or CAA status read all the…
Key result
A history of Kawasaki disease was associated with a significantly increased mean carotid intima-media thickness compared to unaffected controls (0.378 mm vs. 0.360 mm).
Authors
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May support vascular surveillance in Kawasaki survivors; leaves open whether this surrogate predicts clinical events.
Cross-Sectional (n=243)
Single-blind
No
Does a history of Kawasaki disease increase carotid intima-media thickness (a surrogate marker of cardiovascular risk) in children and young adults compared to unaffected controls?
Absolute Event Rate: 0.378% vs 0.36%
p-value: p=<0.0001
A history of Kawasaki disease is associated with increased carotid intima-media thickness, particularly in patients with coronary artery aneurysms, suggesting a persistent vasculopathy.
Dietz et al. (2015) conducted a cross-sectional in Kawasaki Disease (n=243). History of Kawasaki disease vs. Unaffected controls was evaluated on Mean combined carotid intima-media thickness (cIMT) in mm (p=<0.0001). A history of Kawasaki disease was associated with a significantly increased mean carotid intima-media thickness compared to unaffected controls (0.378 mm vs. 0.360 mm).