What question did this study set out to answer?

To test whether carotid intima-media thickness is associated with systemic arterial stiffness in pediatric patients after Kawasaki disease.

July 5, 2006Archives of Disease in ChildhoodOpen Access

Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease

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Why the study?

Is carotid intima-media thickness associated with systemic arterial stiffness in children after Kawasaki disease?

Key Points

To test whether carotid intima-media thickness is associated with systemic arterial stiffness in pediatric patients after Kawasaki disease.
Evaluated a cohort of 72 children: 26 with Kawasaki disease and coronary aneurysms, 24 with Kawasaki disease and normal coronary arteries, and 22 age-matched healthy controls.
Measured carotid intima-media thickness, carotid artery stiffness index, brachioradial pulse wave velocity, and fasting lipid profiles across all groups.
Carotid intima-media thickness was significantly higher in patients with aneurysms (mean 0.41 [SD 0.04] mm, p<0.001) and normal coronary arteries (0.39 [0.04] mm, p=0.008) compared to healthy controls (0.36 [0.04] mm).
Carotid intima-media thickness correlated positively with carotid stiffness index (r=0.40, p=0.001), brachioradial pulse wave velocity (r=0.28, p=0.016), and LDL cholesterol (r=0.31, p=0.009).
Multiple linear regression identified carotid artery stiffness index (beta=0.25, p=0.028) and disease cohort grouping (beta=-0.39, p=0.001; model R²=0.29) as independent determinants of carotid intima-media thickness.

Structured PICO

Is carotid intima-media thickness associated with systemic arterial stiffness in children after Kawasaki disease?

Population

72 children, comprising 26 with Kawasaki disease and coronary aneurysms (group I), 24 with Kawasaki disease and normal coronary arteries (group II), and 22 healthy age-matched children (group III)

Comparator

Healthy age-matched children (group III)

Outcome

Carotid intima-media thickness (IMT) and its association with systemic arterial stiffness (carotid artery stiffness index, brachioradial pulse wave velocity)surrogate

Increased carotid intima-media thickness in children after Kawasaki disease is associated with systemic arterial stiffening, supporting evidence of premature atherosclerosis in this population.

Discussion

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Implication

Carotid thickening was associated with stiffness in post-Kawasaki children; supports premature atherosclerosis hypothesis but should not yet change practice.

Cite This Study

Wong et al. (2006) studied this question.

synapsesocial.com/papers/6a7f977524cfba499c406a23 https://doi.org/10.1136/adc.2006.096628

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Implication

Carotid thickening was associated with stiffness in post-Kawasaki children; supports premature atherosclerosis hypothesis but should not yet change practice.

Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider