Key result
Malignant hyperthermia-susceptible human skeletal muscle receptors displayed a higher affinity for [3H]ryanodine at 0.3 microM Ca2+ (Kd 4.1 nM) than normal receptors (Kd 7.1 nM).
Population
Normal (N) and malignant hyperthermia-susceptible (MH) human skeletal muscle
Comparison
[3H]ryanodine binding assays with varying Ca2+… vs Normal (N) human skeletal muscle
Design
Preclinical
Authors
Loading...
Supports ryanodine receptor hypersensitivity in malignant hyperthermia; leaves open clinical translation and therapeutic targeting.
The ryanodine receptor in malignant hyperthermia-susceptible human skeletal muscle exhibits an unusually high sensitivity to Ca2+, which is further augmented by caffeine.
Valdivia et al. (1991) studied Malignant hyperthermia. Malignant hyperthermia susceptibility vs. Normal human skeletal muscle was evaluated on Binding affinity for [3H]ryanodine at 0.3 microM Ca2+. Malignant hyperthermia-susceptible human skeletal muscle receptors displayed a higher affinity for [3H]ryanodine at 0.3 microM Ca2+ (Kd 4.1 nM) than normal receptors (Kd 7.1 nM).
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: