Key result
Codonopsis lanceolata extract significantly decreased systolic blood pressure and, in stage 1 hypertension, reduced high sensitivity C-reactive protein (P=0.020) and malondialdehyde (P=0.039).
Why the study?
Codonopsis lanceolata extract demonstrated antihypertensive effects in hypertensive rats, but its ability to prevent hypertension in prehypertensive individuals required investigation.
Does Codonopsis lanceolata extract reduce systolic blood pressure in prehypertensive adults?
RCT (n=80)
Double-blind
1:1
Does Codonopsis lanceolata extract reduce systolic blood pressure in prehypertensive adults?
Codonopsis lanceolata extract may improve endothelial function, inflammation, and lipid peroxidation while reducing systolic blood pressure in prehypertensive adults.
CL extract lowered systolic BP in prehypertension; extends rat findings to humans but requires larger trials before practice change.
Codonopsis lanceolata (CL) extract was shown to have antihypertensive effects in hypertensive rats. This randomized controlled trial was designed to investigate the ability of CL extract to prevent hypertension (HTN) in prehypertensive subjects. Eighty subjects aged 19-60 years with a systolic blood pressure (BP) of 120-139 mmHg and a diastolic BP of 80-89 mmHg were recruited over 3 months. Subjects were randomized 1:1 to a CL group and a placebo (PL) group and administered CL extract and starch, respectively, for 6 weeks. (BP) was measured and blood sampled at baseline and at the end of the trial. Relative to baseline, systolic BP was significantly decreased, and catalase activity was significantly increased following CL treatment in both the elevated systolic BP and stage 1 HTN subgroups. In the elevated systolic BP subgroup, serum nitrite concentration relative to baseline was significantly increased in CL compared to PL treated subjects (p = .038). In subjects with stage 1 HTN, high sensitivity C-reactive protein (p = .020) and malondialdehyde (p = .039) showed significantly greater reductions from baseline in the CL than in the PL group. In summary, CL was effective in preventing endothelial dysfunction, inflammation, and lipid peroxidation in prehypertensive subjects, with these effects differing according to baseline systolic BP levels.
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Shin et al. (2019) conducted an RCT in Prehypertension (n=80). Codonopsis lanceolata extract vs. Placebo was evaluated on Systolic blood pressure. Codonopsis lanceolata extract significantly decreased systolic blood pressure and, in stage 1 hypertension, reduced high sensitivity C-reactive protein (P=0.020) and malondialdehyde (P=0.039).
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