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September 1, 1984European Heart Journal

Right and left ventricular ejection fraction and left ventricular volume changes at rest and during exercise in normal subjects

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Key result

Upright submaximal exercise significantly increased RVEF from 44% to 60% and LVEF from 62% to 76% (P<0.001 for both) compared to rest in normal subjects.

Why the study?

Does upright submaximal exercise alter right and left ventricular ejection fractions and volumes compared to rest in normal subjects?

Population

22 normal subjects

Comparison

Upright submaximal exercise vs Rest

Design

Cross-sectional

Authors

IBI. BrynjolfUniversity of CopenhagenHKHenning KelbækInterventional / Structural CardiologyOMO. MunckUniversity of Copenhagen

Discussion

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Implication

Normative biventricular EF responses during upright exercise in healthy subjects; leaves open relevance to patients with cardiovascular disease.

Study Design

Type

Observational (n=22)

Structured PICO

Does upright submaximal exercise alter right and left ventricular ejection fractions and volumes compared to rest in normal subjects?

P
Population
22 normal subjects studied at rest and during upright submaximal exercise.
E
Exposure
Upright submaximal exercise
C
Comparator
Rest
O
Outcome
Changes in right and left ventricular ejection fractions (RVEF and LVEF) and left ventricular end-diastolic and end-systolic volume indices (LVEDVI and LVESVI)surrogate

Main Result

Absolute Event Rate: 60% vs 44%

p-value: p=<0.001

In normal subjects, upright submaximal exercise significantly increases both right and left ventricular ejection fractions, driven by the Starling effect and increased myocardial contractility.

Cite This Study

Brynjolf et al. (1984) conducted an observational in Healthy (n=22). Upright submaximal exercise vs. Rest was evaluated on Right ventricular ejection fraction (RVEF) (p=<0.001). Upright submaximal exercise significantly increased RVEF from 44% to 60% and LVEF from 62% to 76% (P<0.001 for both) compared to rest in normal subjects.

synapsesocial.com/papers/6a93b1eb06b85605447c08a0https://doi.org/10.1093/oxfordjournals.eurheartj.a061738
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Volumetric responses of right and left ventricles during upright exercise in normal subjects1985 · 17 citations
  2. 2Range of normal values for left and right ventricular ejection fraction at rest and during exercise assessed by radionuclide angiocardiography1985 · 127 citations
  3. 3Right ventricular ejection fraction during exercise in normal subjects and in coronary artery disease patients: assessment by multiple-gated equilibrium scintigraphy.1980 · 95 citations
  4. 4Factors with modifying influence on normal right and left ventricular function at rest and during submaximal exercise in healthy volunteers2005 · 7 citations
  5. 5Radionuclide assessment of a normal left ventricular response to exercise in patients without evidence of heart disease1986 · 10 citations