Key result
The combination of ethanol and atenolol caused smaller depressions in left ventricular function than atenolol alone, indicating no harmful acute combined effects in healthy subjects.
Why the study?
Does the acute combination of ethanol and atenolol impair left ventricular function and hemodynamics compared to either agent alone in healthy males?
Population
23 healthy males, aged 23 to 62 years
Comparison
Ethanol 1 g/kg by mouth taken over 60 minutes… vs Each intervention compared against the others
Design
Other
Follow-up
3 hours
Authors
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No additive harm in healthy volunteers; leaves open effects in patients with cardiovascular disease or chronic use.
Does the acute combination of ethanol and atenolol impair left ventricular function and hemodynamics compared to either agent alone in healthy males?
The acute combination of modest alcohol ingestion and atenolol does not cause harmful additive depression of left ventricular function or hemodynamics in healthy men.
Kupari et al. (1983) studied Healthy (n=23). Ethanol and atenolol combination vs. Ethanol alone and atenolol alone was evaluated on Left ventricular function and hemodynamics. The combination of ethanol and atenolol caused smaller depressions in left ventricular function than atenolol alone, indicating no harmful acute combined effects in healthy subjects.
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