What does this research mean for the field?

Acute ethanol ingestion exerts a direct negative inotropic effect on the heart that is normally masked by compensatory autonomic nervous system discharge. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1979CirculationOpen Access

Cardiac effects of acute ethanol ingestion unmasked by autonomic blockade.

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Why the study?

Does acute ethanol ingestion combined with autonomic blockade affect left ventricular function in normal subjects?

Structured PICO

Does acute ethanol ingestion combined with autonomic blockade affect left ventricular function in normal subjects?

Population

9 normal subjects, age 20-35 years

Intervention

Acute ethanol ingestion (180 ml over 60 minutes) combined with autonomic blockade (intravenous propranolol 0.2 mg/kg and atropine 0.04 mg/kg)

Comparator

Autonomic blockade alone and baseline control periods

Outcome

Left ventricular function measured by heart rate, mean velocity of circumferential fiber shortening, and left ventricular pre-ejection period to ejection time ratio (PEP/LVET)surrogate

Acute ethanol ingestion has a negative inotropic effect on the heart that is normally masked by autonomic nervous system discharge.

Discussion

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Implication

Acute ethanol may exert direct negative inotropy unmasked by blockade; leaves open relevance to drinkers or autonomic impairment.

Cite This Study

Child et al. (1979) studied this question.

synapsesocial.com/papers/6a1d6053750575be8d2f6fbf https://doi.org/10.1161/01.cir.59.1.120

Topics

Echocardiography

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Cardiac effects of acute ethanol ingestion unmasked by autonomic blockade.

Structured PICO

Discussion

Implication

Cite This Study

Topics

Cardiac effects of acute ethanol ingestion unmasked by autonomic blockade.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider