Key result
In cultured chick cardiac myocytes, both disruption of F-actin by cytochalasin B and stabilization by phalloidin suppressed swelling-activated chloride current compared to control (68.0 pA/pF).
Swelling of cardiac myocytes initiates dynamic changes in F-actin cytoarchitecture, which is involved in volume transduction and activation of swelling-activated chloride currents.
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Supports F-actin in myocyte volume sensing in vitro; leaves open translation to mammalian cardiac pathophysiology.
Zhang et al. (1997) studied Cultured chick cardiac myocytes. Cytochalasin B and Phalloidin vs. Control was evaluated on Swelling-activated chloride current (I(Cl)). In cultured chick cardiac myocytes, both disruption of F-actin by cytochalasin B and stabilization by phalloidin suppressed swelling-activated chloride current compared to control (68.0 pA/pF).
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