Key result
Proinflammatory cytokines and infection induce growth hormone resistance and alter the IGF system, leading to decreased skeletal muscle protein synthesis.
Proinflammatory cytokines directly and indirectly (via the IGF system) mediate skeletal muscle wasting and growth hormone resistance during infection.
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May explain infection-related muscle wasting; leaves open cytokine or IGF-axis interventions pending prospective trials.
Frost et al. (2004) conducted a review in Infection and sepsis-induced muscle wasting. Proinflammatory cytokines and infection was evaluated. Proinflammatory cytokines and infection induce growth hormone resistance and alter the IGF system, leading to decreased skeletal muscle protein synthesis.
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