Key result
Vitamin K1 prophylaxis prevented significant prolongations in PT (increasing from 11.55 to 14.07 seconds without it), aPTT, and INR associated with cefoperazone-sulbactam in long-term aspirin users.
Why the study?
To explore whether vitamin K1 prophylaxis improves abnormal coagulation function associated with cefoperazone-sulbactam in patients on long-term low-dose aspirin.
Does vitamin K1 prophylaxis prevent abnormal coagulation function in patients on long-term low-dose aspirin receiving cefoperazone-sulbactam?
Observational (n=227)
No
Does vitamin K1 prophylaxis prevent abnormal coagulation function in patients on long-term low-dose aspirin receiving cefoperazone-sulbactam?
Prophylactic vitamin K1 prevents the significant prolongation of coagulation parameters (PT, aPTT, INR) associated with cefoperazone-sulbactam in patients on long-term low-dose aspirin.
Authors
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May reduce coagulation abnormalities with cefoperazone-sulbactam in aspirin users; hypothesis-generating pending randomized confirmation.
Wu et al. (2021) conducted an observational in Patients on long-term low-dose aspirin receiving cefoperazone-sulbactam (n=227). Vitamin K1 prophylaxis vs. Cefoperazone-sulbactam without vitamin K1 was evaluated on Coagulation index (PT, aPTT, INR) before and after receipt of cefoperazone-sulbactam. Vitamin K1 prophylaxis prevented significant prolongations in PT (increasing from 11.55 to 14.07 seconds without it), aPTT, and INR associated with cefoperazone-sulbactam in long-term aspirin users.
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