Key result
In an in vitro model of the Norwood procedure, increasing severity of aortic coarctation caused larger pressure drops and reduced flow to the lower body.
Why the study?
How does the severity of aortic coarctation affect hemodynamics in an in vitro model of the Norwood procedure?
Population
3 patient-specific anatomies reconstructed from magnetic resonance images and rapid prototyped with…
Comparison
Mock circulatory system replicating hemodynamics… vs Comparison across varying degrees of coarctation.
Design
Preclinical
Authors
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Coarctation severity may affect Norwood hemodynamics; hypothesis-generating and requires in vivo validation before clinical use.
How does the severity of aortic coarctation affect hemodynamics in an in vitro model of the Norwood procedure?
In an in vitro model of the Norwood procedure, increasing severity of aortic coarctation leads to a larger pressure drop and reduced flow to the lower body, favoring upper body and pulmonary circulation.
Biglino et al. (2011) studied Norwood palliation hemodynamics. Aortic coarctation (moderate and severe) vs. No coarctation was evaluated on Pressure drop and volume distribution. In an in vitro model of the Norwood procedure, increasing severity of aortic coarctation caused larger pressure drops and reduced flow to the lower body.
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