Key result
Pregnant women with acute VTE presented less often with symptomatic pulmonary embolism than non-pregnant women (11% vs 39%), with 40% of pregnancy-related VTE occurring in the first trimester.
Why the study?
What are the clinical characteristics, timing, and outcomes of acute VTE during pregnancy and postpartum compared to non-pregnant women?
Population
848 women aged <47 years with objectively confirmed, symptomatic acute venous thromboembolism, including 72…
Comparison
Low-molecular-weight heparin vs Non-pregnant women in the same age range with…
Design
Cohort
Follow-up
Through delivery and postpartum period
Authors
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May support early thromboprophylaxis consideration in pregnancy; leaves open postpartum recurrence-bleeding balance pending prospective data.
Cohort (n=848)
What are the clinical characteristics, timing, and outcomes of acute VTE during pregnancy and postpartum compared to non-pregnant women?
Absolute Event Rate: 11% vs 39%
A significant proportion of pregnancy-associated VTE occurs in the first trimester, suggesting that when indicated, thromboprophylaxis should be initiated early, while postpartum management must balance recurrence against a notable risk of major bleeding.
Blanco‐Molina et al. (2007) conducted a cohort in Acute venous thromboembolism (VTE) (n=848). Pregnancy vs. Non-pregnant women was evaluated on Symptomatic pulmonary embolism presentation. Pregnant women with acute VTE presented less often with symptomatic pulmonary embolism than non-pregnant women (11% vs 39%), with 40% of pregnancy-related VTE occurring in the first trimester.
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