Why the study?
Are HLA class II polymorphisms associated with genetic susceptibility to primary dilated cardiomyopathy in Tunisian patients?
Are HLA class II polymorphisms associated with genetic susceptibility to primary dilated cardiomyopathy in Tunisian patients?
Specific HLA class II alleles (HLA-DRB1*0401, HLA-DQB1*0302, HLA-DQB1*0401) are associated with increased susceptibility to primary dilated cardiomyopathy in the Tunisian population, while others appear protective.
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These alleles were associated with DCM susceptibility in Tunisians; leaves open generalizability and clinical utility pending prospective validation.
Mehri et al. (2010) studied this question.
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