Key result
Implantation of heating devices in calves showed a progressive decrease in tissue temperature elevation over 7 weeks (e.g., from 6.4 to 3.7 °C at 0.08 W/cm2), suggesting heat adaptation via angiogenesis.
Population
11 calves (H-series) and 3 total artificial heart (TAH) cases
Design
Preclinical
Follow-up
7 weeks
Authors
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Tissue adaptation may mitigate heat risks in chronic implants; leaves open human translation for total artificial hearts.
Tissues surrounding heat sources such as a total artificial heart adapt to chronic heat loads by increasing heat dissipation, likely through angiogenesis, resulting in decreased local temperature elevations over time.
Davies et al. (1994) studied Tissue adaptation to chronic heat load (n=14). Heating devices producing constant heat fluxes was evaluated on Temperature elevations above body temperature (delta T) at the muscle heater surface. Implantation of heating devices in calves showed a progressive decrease in tissue temperature elevation over 7 weeks (e.g., from 6.4 to 3.7 °C at 0.08 W/cm2), suggesting heat adaptation via angiogenesis.
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