Key result
Maximum glucose requirement at diagnosis in children with congenital hyperinsulinism was significantly correlated with the presence of ventricular hypertrophy (OR 1.1; 95% CI 1.0-1.2; P=0.04).
Population
49 children with congenital hyperinsulinism (CHI)
Design
Cohort
Follow-up
median 178 (range 45-390) days
Authors
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May support echocardiography in severe congenital hyperinsulinism; leaves open whether monitoring alters outcomes.
Observational (n=49)
Odds Ratio: 1.1 (95% CI 1–1.2)
p-value: p=0.04
A significant proportion of children with congenital hyperinsulinism have ventricular hypertrophy at diagnosis, which correlates with disease severity and may persist, warranting long-term cardiac monitoring.
Banerjee et al. (2012) conducted an observational in Congenital hyperinsulinism (n=49). Maximum glucose requirement at diagnosis was evaluated on Presence of ventricular hypertrophy at initial echocardiography (OR 1.1, 95% CI 1.0-1.2, p=0.04). Maximum glucose requirement at diagnosis in children with congenital hyperinsulinism was significantly correlated with the presence of ventricular hypertrophy (OR 1.1; 95% CI 1.0-1.2; P=0.04).
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