Key result
Exogenous norepinephrine significantly increased 1,2-diacylglycerol content in rat myocardium by 80% over unstimulated controls at 60 minutes, an effect inhibited by alpha1-adrenergic antagonists.
Myocardial norepinephrine-related 1,2-DG formation is associated with alpha 1-adrenergic receptors.
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Animal data link myocardial diacylglycerol to alpha1 signaling; leaves open relevance to human heart failure or ischemia.
Okumura et al. (1988) studied this question. Exogenous norepinephrine vs. Unstimulated controls was evaluated on 1,2-diacylglycerol (DG) content in the myocardium. Exogenous norepinephrine significantly increased 1,2-diacylglycerol content in rat myocardium by 80% over unstimulated controls at 60 minutes, an effect inhibited by alpha1-adrenergic antagonists.
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