Key result
Anti-CCP antibody positivity in rheumatoid arthritis patients was associated with significantly higher carotid intima-medial thickness (P=0.029) and lower left ventricular ejection fraction (P=0.01).
Why the study?
Does anti-CCP antibody positivity predict adverse cardiovascular profile in patients with established rheumatoid arthritis?
Population
80 patients with established rheumatoid arthritis without known cardiovascular risk factors, known heart…
Comparison
Anti-CCP antibody positivity vs Anti-CCP antibody negativity
Design
Cross-sectional
Authors
Loading...
May warrant closer CV monitoring in anti-CCP-positive RA; leaves open causal role and need for prospective validation.
Cross-Sectional (n=80)
Does anti-CCP antibody positivity predict adverse cardiovascular profile in patients with established rheumatoid arthritis?
Anti-CCP antibody positivity in established rheumatoid arthritis is associated with increased carotid intima-medial thickness and myocardial dysfunction, suggesting a higher risk for cardiovascular morbidity.
Arnab et al. (2013) conducted a cross-sectional in Rheumatoid arthritis (n=80). Anti-CCP antibody positivity vs. Anti-CCP antibody negativity was evaluated on Cardiovascular complications as documented by carotid intima medial thickness and abnormal echocardiography. Anti-CCP antibody positivity in rheumatoid arthritis patients was associated with significantly higher carotid intima-medial thickness (P=0.029) and lower left ventricular ejection fraction (P=0.01).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: