Key result
Tissue factor-initiated thrombin generation and protease-activated receptor signaling play crucial roles in cancer metastasis and angiogenesis-dependent tumor growth.
Population
Cancer models, including metastatic tumor cells and tissue factor (TF) cytoplasmic-domain-deleted mice
Design
Review
Authors
Loading...
Does not support changing anticoagulation in cancer; leaves open therapeutic targeting of this axis pending trials.
This review highlights the complex interplay between tissue factor, thrombin, and protease-activated receptors (PARs) in driving cancer metastasis and tumor angiogenesis.
Ruf et al. (2006) conducted a review in Cancer. Tissue factor-initiated thrombin generation and protease-activated receptor signaling play crucial roles in cancer metastasis and angiogenesis-dependent tumor growth.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: