Key result
In an in vitro cardiopulmonary bypass model, bivalirudin was effectively eliminated by hemofiltration and plasmapheresis, achieving elimination rates of 65% with a large-pore hemofilter and 69% with a plasmapheresis filter.
Why the study?
Does the type of filter system affect the elimination rate of bivalirudin in an in vitro simulated cardiopulmonary bypass circuit?
Population
In vitro simulated cardiopulmonary bypass circuit using 25 single filters.
Comparison
Filtration of bivalirudin using different… vs Comparison among the 5 different filter systems.
Design
Preclinical
Authors
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May support large-pore hemofiltration for bivalirudin clearance in CPB; leaves open clinical translation pending in vivo data.
Does the type of filter system affect the elimination rate of bivalirudin in an in vitro simulated cardiopulmonary bypass circuit?
In an in vitro model of cardiopulmonary bypass, bivalirudin elimination correlates with filter pore size, suggesting specific hemofilters can effectively clear the drug without removing essential coagulation factors.
Koster et al. (2003) studied In vitro simulation of cardiopulmonary bypass (n=25). Hemofilter and plasmapheresis systems vs. Comparison among different filter types was evaluated on Percentage decrease in bivalirudin concentration. In an in vitro cardiopulmonary bypass model, bivalirudin was effectively eliminated by hemofiltration and plasmapheresis, achieving elimination rates of 65% with a large-pore hemofilter and 69% with a plasmapheresis filter.
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