Key result
Plasmapheresis filters eliminated more recombinant hirudin than hemofilters (60%-70% vs 15%-42%) in less time (80 vs 180 s) during simulated cardiopulmonary bypass.
Why the study?
Do plasmapheresis filter systems improve the elimination of recombinant hirudin compared to hemofilter systems in a simulated cardiopulmonary bypass model?
Population
Closed in vitro simulated cardiopulmonary bypass system testing 30 filters
Comparison
Plasmapheresis filter systems vs Hemofilter systems
Design
Preclinical
Authors
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Plasmapheresis may speed hirudin removal in CPB; animal model data leave open clinical translation and safety.
Do plasmapheresis filter systems improve the elimination of recombinant hirudin compared to hemofilter systems in a simulated cardiopulmonary bypass model?
In a simulated cardiopulmonary bypass model, plasmapheresis filters provided more rapid and complete elimination of recombinant hirudin compared to standard hemofilters.
Koster et al. (2000) studied Simulated cardiopulmonary bypass (n=30). Plasmapheresis filters vs. Hemofilters was evaluated on Elimination of r-hirudin. Plasmapheresis filters eliminated more recombinant hirudin than hemofilters (60%-70% vs 15%-42%) in less time (80 vs 180 s) during simulated cardiopulmonary bypass.
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