Population
Patients with renal insufficiency requiring alternative anticoagulation, such as for heparin-induced…
Design
Review
Authors
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Supports dose reduction and specialized monitoring in renal impairment; leaves open prospective validation of assays and reversal strategies.
In patients with renal insufficiency, recombinant hirudin requires careful dose reduction and specialized monitoring to prevent accumulation and bleeding, though high-volume hemofiltration can manage overdose.
Karl-Georg Fischer (2002) studied this question.
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