Removal of Lepirudin, a Recombinant Hirudin, by Hemodialysis, Hemofiltration, or Plasmapheresis
Key result
Hemodialysis, hemofiltration, and plasmapheresis can remove lepirudin from the blood, with efficacy highly dependent on the membrane material used in the filtration system.
Why the study?
Can lepirudin be effectively removed by hemodialysis, hemofiltration, or plasmapheresis in patients with renal failure?
Population
Patients with heparin-induced thrombocytopenia and renal failure
Design
Review
Authors
Discussion
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Implication
May inform management of lepirudin accumulation in renal failure; leaves open membrane-specific trials and outcome data.
Structured PICO
Can lepirudin be effectively removed by hemodialysis, hemofiltration, or plasmapheresis in patients with renal failure?
P
Population
Patients with heparin-induced thrombocytopenia and renal failure
I
Intervention
Hemodialysis, hemofiltration, or plasmapheresis
O
Outcome
Removal of lepirudin from the bloodsurrogate
Lepirudin can be removed by hemodialysis, hemofiltration, or plasmapheresis, which is critical for managing accumulation in patients with renal failure since no specific antidote exists.
Limitations
- Current literature on the removal of lepirudin by dialysis or plasmapheresis is limited
Cite This Study
Willey et al. (2002) conducted a review in Heparin-induced thrombocytopenia in patients with renal failure. Hemodialysis, hemofiltration, or plasmapheresis was evaluated on Removal of lepirudin. Hemodialysis, hemofiltration, and plasmapheresis can remove lepirudin from the blood, with efficacy highly dependent on the membrane material used in the filtration system.